Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusion MRI findings in phenylketonuria.

R N Sener1

  • 1Department of Radiology, Ege University Hospital, 35100, Bornova, Izmir, Turkey. rnsener@med.ege.edu.tr

European Radiology
|January 28, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Malignant oculomotor schwannoma: diffusion MR imaging.

Journal of neuroradiology = Journal de neuroradiologie·2006
Same author

Regression of nodular liver lesions in Wilson's disease.

Acta radiologica (Stockholm, Sweden : 1987)·2006
Same author

Brain magnetic resonance imaging in tyrosinemia.

Acta radiologica (Stockholm, Sweden : 1987)·2005
Same author

Walker-Warburg syndrome: diffusion MR imaging.

Journal of neuroradiology = Journal de neuroradiologie·2005
Same author

Papillary glioneuronal tumor.

AJR. American journal of roentgenology·2005
Same author

Diffusion MRI in the postmortem brain: case report.

Journal of neuroradiology = Journal de neuroradiologie·2005

Phenylketonuria (PKU) patients on diet show distinct diffusion MRI patterns. These patterns, restricted and increased diffusion, may indicate different histopathological changes or disease stages in PKU.

Area of Science:

  • Neuroimaging
  • Metabolic Disorders
  • Radiology

Background:

  • Phenylketonuria (PKU) is an inherited metabolic disorder requiring early dietary intervention.
  • Mentally normal PKU patients under long-term dietary control were assessed using diffusion MRI.
  • Understanding brain changes in treated PKU is crucial for long-term management.

Observation:

  • Diffusion MRI was performed using spin-echo, echo-planar imaging at 1.5 T.
  • Heavily diffusion-weighted (b=1000 mm²/s) images and apparent diffusion coefficient (ADC) values were analyzed.
  • Two distinct diffusion patterns were observed in the two patients studied.

Findings:

  • Restricted diffusion pattern: high signal on b=1000 images with low ADC values (0.46–0.57 x 10⁻³ mm²/s).

Related Experiment Videos

  • Increased diffusion pattern: normal signal on b=1000 images with high ADC values (1.37–1.63 x 10⁻³ mm²/s).
  • These findings suggest potential differences in brain histopathology or disease progression.

    • Implications:

    • Diffusion MRI may reveal distinct neuropathological states in treated PKU.
    • Further research is needed to correlate these patterns with specific histopathological findings.
    • This could lead to more refined diagnostic or prognostic tools for PKU patients.