Related Experiment Video

Updated: Aug 8, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

DNA vaccines: successes and limitations in cancer and infectious disease

Devin B Lowe1, Michael H Shearer, Ronald C Kennedy

  • 1Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, 79430, USA.

Journal of Cellular Biochemistry
|January 28, 2006
PubMed

Insights

DNA vaccines show promise for treating cancer and infectious diseases by eliciting targeted immune responses. Despite progress, challenges remain in their widespread prophylactic and therapeutic application.

Area of Science:

  • Investigational vaccine technology utilizing plasmid DNA for disease prevention and treatment.

Background:

  • Plasmid DNA vaccines represent a significant advancement in immunology.
  • Their application is being explored for diverse conditions, including cancers and infectious diseases.

Observation:

  • Significant progress has been achieved in harnessing DNA vaccines to generate specific and effective immune responses.
  • Despite advancements, challenges persist in the practical implementation of DNA vaccines.

Findings:

  • The study discusses the successes and ongoing difficulties associated with DNA vaccine technology.
  • It highlights the potential of plasmid DNA in both prophylactic and therapeutic settings.

Implications:

  • Understanding these challenges is crucial for the future development and broader adoption of DNA vaccines.
  • Further research is needed to overcome existing obstacles and realize the full potential of this vaccination strategy.

More Related Videos

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid07:24

Production of High-Titer Recombinant Newcastle Disease Virus from Allantoic Fluid

Published on: May 25, 2022

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.