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Anaphylaxis to omeprazole: diagnosis and desensitization protocol
Ronit Confino-Cohen1, Arnon Goldberg
1Allergy and Clinical Immunology Unit, Meir General Hospital, Kfar-Saba, Tel-Aviv University Sackler School of Medicine, Tel-Aviv, Israel. ronitco@clalit.org.il
Summary
Patients experiencing omeprazole-induced anaphylaxis can be safely treated with a novel oral desensitization protocol. This method was confirmed effective through skin testing, enabling successful drug administration.
Area of Science:
- Pharmacology
- Allergy and Immunology
Background:
- Omeprazole, a proton pump inhibitor, rarely causes immediate-type hypersensitivity reactions.
- Recurrent anaphylaxis to omeprazole necessitates understanding its immediate-type hypersensitivity mechanism.
Observation:
- Skin testing with omeprazole and pantoprazole confirmed immediate-type hypersensitivity.
- A novel oral desensitization protocol was developed for omeprazole administration.
Findings:
- The desensitization protocol successfully enabled uneventful administration of full-dose omeprazole.
- Skin test wheal sizes were significantly reduced after desensitization, confirming its efficacy.
Implications:
- This protocol offers a safe option for patients with omeprazole-induced anaphylaxis.
- Successful desensitization allows for continued use of omeprazole when clinically indicated.