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Topical tacrolimus in Hailey-Hailey disease.
F Rocha Paris1, A Fidalgo, J Baptista
1Dermatology Department, Desterro Hospital, Lisbon, Portugal.
International Journal of Tissue Reactions
|January 31, 2006
Summary
Hailey-Hailey disease, a rare blistering condition, can be effectively treated with tacrolimus ointment. This topical treatment offers a promising alternative for managing familial benign chronic pemphigus.
Area of Science:
- Dermatology
- Immunology
Background:
- Hailey-Hailey disease (HHD), or familial benign chronic pemphigus, is a rare autosomal-dominant blistering disorder.
- It typically presents with recurrent vesicles and erosions in skin folds, predominantly affecting females.
- Current treatments, primarily topical corticosteroids, have limitations due to side effects and lesion location.
Observation:
- A 60-year-old female patient presented with extensive Hailey-Hailey disease.
- Lesions were located in axillary, groin, cervical, antecubital, inframammary, and abdominal folds.
- The patient had previously faced limitations with conventional therapies.
Findings:
- Treatment with 0.1% tacrolimus ointment, applied twice daily, was initiated.
- Significant clinical improvement was observed within two weeks of treatment.
- Complete remission of lesions was achieved in four weeks.
Implications:
- Topical tacrolimus demonstrates efficacy as a treatment for Hailey-Hailey disease.
- This offers a potential alternative to corticosteroids, addressing their limitations.
- Sustained remission was noted over a 10-month follow-up, suggesting long-term benefit.