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Within-host evolution and virulence in microparasites.

Jean-Baptiste André1, Bernard Godelle

  • 1Laboratoire Génome, Populations, Interactions, Adaptation, USTL-IFREMER-CNRS UMR 5171, Université des Sciences et Techniques du Languedoc, Montpellier, France. jeanbaptisteandre@gmail.com

Journal of Theoretical Biology
|January 31, 2006
PubMed
Summary

Within-host evolution impacts microparasite infections. Mutations reducing transmissibility are favored, affecting transmission more than duration, suggesting novel therapeutic strategies.

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Area of Science:

  • Microbiology and Epidemiology
  • Evolutionary Biology
  • Infectious Disease Dynamics

Background:

  • Infections are microbial populations subject to demographic and evolutionary changes.
  • Understanding within-host evolution is crucial for microparasite biology.

Purpose of the Study:

  • To analyze the consequences of within-host evolutionary changes on infectious traits.
  • To model the impact of mutations affecting virulence, transmissibility, and clearance.

Main Methods:

  • Development of an epidemiological model incorporating within-host evolution.
  • Simulation of infections invaded by locally favored mutations.
  • Analysis of the effects of mutations on transmissibility and infection duration.

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Main Results:

  • In durable infections, reduced transmissibility is less costly than reduced lifespan.
  • Mutations decreasing transmissibility can reach high frequencies or fixation.
  • Within-host evolution impacts infection transmission more than duration.

Conclusions:

  • Within-host evolution can lead to suboptimal infection traits, primarily affecting transmission.
  • Management of within-host evolution offers a potential novel therapeutic approach for infections.