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Comparative Mouse Genomics Centers Consortium: the Mouse Genotype Database.

Jesse C Wiley1, Manjula Prattipati, Ching-Ping Lin

  • 1Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA. jwiley@u.washington.edu

Mutation Research
|January 31, 2006
PubMed
Summary
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The Comparative Mouse Genomics Centers Consortium (CMGCC) develops mouse models for human single nucleotide polymorphisms (SNPs) to study disease susceptibility. These genetic models aid in understanding human pathologies linked to cell cycle, DNA replication, and repair genes.

Area of Science:

  • Genomics
  • Translational Medicine
  • Bioinformatics

Background:

  • The National Institute of Environmental Health Sciences (NIEHS) Environmental Genome Project supports the Comparative Mouse Genomics Centers Consortium (CMGCC).
  • Identifying human single nucleotide polymorphisms (SNPs) associated with disease susceptibility is a key challenge in public health.
  • Genetic mouse models are crucial for studying the impact of human genetic variations on disease.

Purpose of the Study:

  • To create genetic mouse models that mimic human SNPs.
  • To investigate the role of SNPs in cell cycle control, DNA replication, and DNA repair genes.
  • To facilitate research into human pathologies linked to genetic variations.

Main Methods:

  • Development of genetically modified mouse models.

Related Experiment Videos

  • Focus on genes involved in cell cycle control, DNA replication, and DNA repair.
  • Generation of informatics resources for data sharing and analysis.

    • Main Results:

    • Establishment of a consortium focused on mouse model development for human SNPs.
    • Creation of a Genotype Database for accessing and tracking mouse models.
    • Public and consortium-specific access to available and developing mouse models.

    Conclusions:

    • The CMGCC provides valuable genetic mouse models for studying human disease susceptibility.
    • Informatics resources enhance collaboration and data accessibility within the consortium.
    • The CMGCC Genotype Database serves as a central hub for mouse model information.