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Updated: Aug 13, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Exercise training improves low-density lipoprotein oxidability in untrained subjects with coronary artery disease
Sophie Ziegler1, Georg Schaller, Friedrich Mittermayer
1Department of Angiology, Medical University of Vienna, Austria. sophie.ziegler@meduniwien.ac.at
Unlabelled:
Exercise training improves low-density lipoprotein oxidability in untrained subjects with coronary artery disease.
Objective:
To test the hypothesis that regular exercise alters low-density lipoprotein (LDL) oxidability in patients with coronary artery disease.
Design:
Longitudinal study.
Setting:
General hospital and community.
Participants:
Thirteen patients.
Interventions:
Training program comprising running bouts twice weekly over 2 months.
Main Outcome Measures:
Plasma lipid profile, oxidized LDL, and rate (Ox(rate)) and amount (Ox(amount)) of LDL reaction products were measured at baseline and after 2 months of training. Brachial artery endothelium-dependent and -independent vasodilation was assessed by use of ultrasound.
Results:
Lipid profile and oxidized LDL remained unchanged, but mean Ox(rate) and Ox(amount) +/- standard deviation were reduced from 2.5+/-1.5nmol.mgLDL(-1).min(-1) and 120.3+/-75.3nmol/mgLDL at baseline to 0.4+/-0.2nmol.mgLDL(-1).min(-1) and 21.3+/-11.4nmol/mgLDL after training (P<.05), respectively. Brachial artery vasodilation was suggested to be improved, but statistical significance was not reached in the small cohort under study.
Conclusions:
Aerobic training enhances the resistance of LDL to oxidation in patients with coronary artery disease, which may play a role in the favorable effects of exercise.
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