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Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice
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Published on: November 3, 2013

Objective evidence for the reversibility of nerve injury in diabetic neuropathic cachexia

Jaspreet Grewal, Vera Bril, Gary F Lewis

    Diabetes Care
    |January 31, 2006
    PubMed
    Abstract

    No abstract available in PubMed .

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    DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...