Related Experiment Video
Updated: Aug 13, 2026
MISSION esiRNA for RNAi Screening in Mammalian Cells
Published on: May 12, 2010
siRecords: an extensive database of mammalian siRNAs with efficacy ratings
Yongliang Ren1, Wuming Gong, Qiqi Xu
1Department of Neuroscience, University of Minnesota Minneapolis, MN 55455, USA.
Unlabelled:
Short interfering RNAs (siRNAs) have been gaining popularity as the gene knock-down tool of choice by many researchers because of the clean nature of their workings as well as the technical simplicity and cost efficiency in their applications. We have constructed siRecords, a database of siRNAs experimentally tested by researchers with consistent efficacy ratings. This database will help siRNA researchers develop more reliable siRNA design rules; in the mean time, siRecords will benefit experimental researchers directly by providing them with information about the siRNAs that have been experimentally tested against the genes of their interest. Currently, more than 4100 carefully annotated siRNA sequences obtained from more than 1200 published siRNA studies are hosted in siRecords. This database will continue to expand as more experimentally tested siRNAs are published.
Availability:
The siRecords database can be accessed at http://siRecords.umn.edu/siRecords/
Related Concept Videos
02:15Experimental RNAi
02:30siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...