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Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: case study
Jeffrey C Allen1, Alexander R Judkins, Marc K Rosenblum
1Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.
Abstract:
We report an atypical teratoid/rhabdoid tumor arising in a ganglioglioma from an 11-year-old male who had been treated over a nine-year period. A combined histologic, immunohistochemical, and molecular genetic analysis confirmed this diagnosis. Molecular genetic studies demonstrated a mutation in exon 9 of the INI1 gene in the tumor, which was not present in the patient's blood. This report is the first to describe progression of a ganglioglioma to atypical teratoid/rhabdoid tumor.