Related Experiment Videos
Long-term changes in trace elements in patients undergoing chronic hemodialysis.
Yi-Yueh Hsieh1, Wu-Shiun Shen, Li-Yu Lee
1Department of Pathology, Chang Gung Memorial Hospital, Lin-Kuo Medical Center, Tao-Yuan, Taiwan.
Biological Trace Element Research
|January 31, 2006
Summary
Hemodialysis patients show imbalances in essential trace elements. This study found lower selenium, zinc, and manganese, but higher nickel levels, with nickel imbalance worsening over time.
Area of Science:
- Nephrology
- Trace Element Analysis
- Biochemistry
Background:
- Dialysis dementia linked to aluminum toxicity since the 1980s.
- Incomplete understanding of trace element imbalances in hemodialysis (HD) patients.
- Advancements in Inductively Coupled Plasma-Mass Spectrometry (ICP/MS) enable new research.
Purpose of the Study:
- Evaluate serum trace element concentrations (Cu, Se, Zn, Mn, Ni) in HD patients versus controls.
- Investigate correlation between HD duration and trace element imbalance severity.
- Validate ICP/MS utility for trace element research and patient monitoring.
Main Methods:
- Utilized ICP/MS for serum trace element analysis.
- Compared HD patients with healthy, age-matched controls.
- Analyzed trace element levels based on HD treatment duration.
Main Results:
- HD patients exhibited significantly lower serum Se, Zn, and Mn.
- HD patients showed significantly higher serum Ni concentrations.
- Positive correlation observed between HD duration and Ni imbalance severity.
- No significant difference in serum Cu levels between groups.
Conclusions:
- Confirms relative nickel excess and deficiencies of selenium, zinc, and manganese in hemodialysis patients.
- Highlights the value of ICP/MS for studying trace element imbalances in HD.
- Suggests ICP/MS can aid in clinical monitoring of individual HD patients.