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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

Renal function and cardiac angiography

Ayumi Niboshi1, Masashi Nishida, Toshiyuki Itoi

  • 1Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi-Hirokoji, Kamikyo-ku Kyoto, Japan.

Indian Journal of Pediatrics
|January 31, 2006
PubMed

Insights

Non-ionic contrast media can cause temporary kidney problems in children with heart disease. Neonates, infants, and those receiving larger doses or having cyanotic heart disease are at higher risk for contrast medium-induced nephropathy.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Imaging
  • Radiology

Background:

  • Cardiovascular disease necessitates diagnostic imaging procedures.
  • Contrast media are essential for angiography but can pose risks to renal function.
  • Understanding contrast medium-induced nephropathy in pediatric populations is crucial.

Purpose of the Study:

  • To evaluate the impact of non-ionic contrast media on renal function in pediatric patients undergoing cardiovascular angiography.
  • To identify risk factors associated with contrast medium-induced nephropathy in this cohort.

Main Methods:

  • Renal function was assessed in 98 children with cardiovascular disease before and after angiography.
  • Serum creatinine (s-Cre) and urinary biomarkers (u-NAG/Cre, u-BMG/Cre, u-AMG/Cre) were measured.
  • Data were analyzed based on age, contrast volume, and cyanotic status.

Main Results:

  • Transient increases in urinary biomarkers (u-NAG/Cre, u-AMG/Cre, u-BMG/Cre) indicated renal tubular dysfunction 12 hours post-angiography.
  • Higher elevations were observed in neonates/infants, those receiving >5 ml/kg contrast, and cyanotic patients.
  • Serum creatinine levels remained unchanged, suggesting tubular, not glomerular, injury.

Conclusions:

  • Non-ionic contrast media can induce transient renal tubular dysfunction in children with cardiovascular disease.
  • Risk factors include young age (neonates/infants), higher contrast volumes (>5 ml/kg), and cyanotic heart disease.
  • While renal function recovers long-term, careful consideration is needed to mitigate contrast medium-induced nephropathy in at-risk pediatric patients.
Abstract

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