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Updated: Jul 26, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
Adiponectin, an adipocyte-derived hepatic insulin sensitizer regulation during development
Ja-Young Kim1, Philipp E Scherer
1Department of Cell Biology, Albert Einstein College of Medicine, Morris Park Avenue, Bronx, NY 10461, USA.
Abstract:
A large body of clinical data, supported by genetic and pharmacological evidence, has demonstrated potent insulin-sensitizing effects of the adipocyte-derived secretory factor adiponectin. In adults, plasma adiponectin is generally negatively correlated with BMI and positively correlated with systemic insulin sensitivity. Only a limited number of studies have been performed in newborns, children and adolescents. Here we summarize the results from these recent findings in younger cohorts and discuss these results in context of the much vaster literature on adiponectin levels in lean, obese and diabetic adults.
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