Related Experiment Video
Updated: Aug 13, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Histiocytic sarcoma associated with Hodgkin's disease
Elena Doina Murărescu1, Rodica Lighezan, D Negru
1Department of Pathology, "Gr. T. Popa" University of Medicine and Pharmacy, Iassy. doinamurarescu@yahoo.com
Summary
This case report details a rare instance of histiocytic sarcoma in a young female patient diagnosed with Hodgkin
Area of Science:
- Oncology
- Pathology
- Hematology
Background:
- Histiocytic sarcoma is a rare malignant neoplasm.
- The association between Langerhans' cell histiocytosis and Hodgkin's disease is known, but histiocytic sarcoma co-occurrence is infrequent.
Observation:
- A 20-year-old female presented with Hodgkin's disease and a sternal tumor mass.
- The sternal mass was diagnosed as histiocytic sarcoma.
Findings:
- Immunohistochemical analysis using S-100, CD 68, CD 34, CD 15, CD 30, Vim, and NFAP antibodies confirmed the diagnosis.
- Electron microscopy revealed an absence of Birbeck granules in the malignant histiocytes, differentiating it from Langerhans' cell histiocytosis.
Implications:
- This case highlights a rare co-occurrence of Hodgkin's disease and histiocytic sarcoma.
- Definitive diagnosis relies on comprehensive immunohistochemistry and electron microscopy.
- Understanding rare associations aids in accurate diagnosis and patient management in hematologic malignancies.
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:27Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...