Related Experiment Video
Updated: Aug 13, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
[Current and future prospects in haemostasis]
1Institut für Experimentelle Hämatologie und Transfusionsmedizin, Universitätsklinik Bonn, Sigmund-Freud-Str. 25, 53105 Bonn. Johannes.Oldenburg@ukb.uni-bonn.de
Abstract:
Solving the human genome and new technical tools are nowadays rapidly increasing the knowledge of haemostasis. This includes the identification of novel genes, the understanding of complex phenotypes as thromboembolic disorders, the scientific exploration of the involved proteins by means of crystal structure, protein-protein-interactions and protein expression profiles as well as the development of new and more selectively acting anticoagulant drugs. The impact of haemostasis proteins in fields beyond haemostasis such as wound healing, angiogenesis, inflammation, immune system, and tumour growth is becoming more evident. Patients will profit from these developments by individualised prevention and therapy regimens, including future approaches of regenerative medicine as stem cell and gene therapy.
More Related Videos
Related Concept Videos
Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Regulation of Hematopoietic Stem Cells
Coagulation
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...

