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Homocysteine level and coronary artery disease
M B Sharif Kazemi1, K Eshraghian, G R Omrani
1Department of Internal Medicine Shiraz University of Medical Sciences, Shiraz, Iran.
Angiology
|January 31, 2006
Summary
High homocysteine levels are linked to coronary artery disease (CAD) in an Iranian population. Elevated homocysteine independently predicts CAD severity, especially in individuals without other risk factors.
Area of Science:
- Cardiovascular Medicine
- Clinical Biochemistry
- Epidemiology
Background:
- Atherosclerosis, particularly coronary artery disease (CAD), is a leading global cause of mortality.
- Identifying risk factors for CAD is crucial for effective prevention strategies.
- The homocysteine theory has implicated serum homocysteine levels as a potential CAD risk factor since 1969.
Purpose of the Study:
- To investigate the association between hyperhomocysteinemia and CAD in an Iranian population.
- To determine if homocysteine is an independent risk factor for CAD.
- To explore the correlation between homocysteine levels and the extent of coronary artery involvement.
Main Methods:
- A case-control study involving 197 individuals undergoing coronary angiography.
- Measurement of serum homocysteine levels using the ELISA method.
- Statistical analysis including independent sample t test, ANOVA, and multiple linear regression.
Main Results:
- Patients with abnormal angiography (CAD) exhibited significantly higher homocysteine levels compared to those with normal reports (p = 0.001).
- Hyperhomocysteinemia was present in 28.1% of patients with normal angiography.
- A significant linear correlation was found between homocysteine levels and the number of diseased coronary arteries (p = 0.000), particularly in individuals without other risk factors.
Conclusions:
- Hyperhomocysteinemia is independently associated with CAD in the studied Iranian population.
- Plasma homocysteine levels may serve as a noninvasive predictor for the extent of coronary artery disease.
- Further prospective studies are needed to confirm the predictive value of homocysteine levels for CAD severity.
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