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Updated: Aug 13, 2026

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
Published on: September 16, 2018
Effects of two Prunella species on lymphocyte proliferation and nitric oxide production
U Sebnem Harput1, Iclal Saracoglu, Yukio Ogihara
1Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100 Sihhiye, Ankara, Turkey. sharput@hacettepe.edu.tr
Abstract:
Water extracts of Prunella vulgaris and P. laciniata have been investigated for their immunomodulatory and antiinflammatory activities concerning their effect on the mitogenic response of murine splenocytes and nitric oxide production by murine peritoneal macrophages in vitro. It was found that both extracts stimulated the proliferation of T-lymphocytes and suppressed NO production in lipopolysaccharide-stimulated macrophages dose dependently without any cytotoxicity.
