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Related Experiment Videos

Pharmaceutical co-crystals.

Peddy Vishweshwar1, Jennifer A McMahon, Joanna A Bis

  • 1Department of Chemistry, University of South Florida, CHE205, Tampa, 33620, USA.

Journal of Pharmaceutical Sciences
|January 31, 2006
PubMed
Summary
This summary is machine-generated.

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Crystal engineering enables supramolecular synthesis of new solid forms without altering covalent bonds. This review highlights rational pharmaceutical co-crystal generation for active pharmaceutical ingredients (APIs), showcasing ease of preparation and property diversity.

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Crystallography

Background:

  • Crystal engineering is a key aspect of supramolecular synthesis.
  • It involves the self-assembly of molecules into new solid forms.
  • This process does not require breaking or forming covalent bonds.

Purpose of the Study:

  • To review the application of crystal engineering to active pharmaceutical ingredients (APIs).
  • To emphasize the rational design and generation of pharmaceutical co-crystals.
  • To explore co-crystals as an alternative to traditional API forms.

Main Methods:

  • Review of crystal engineering principles applied to APIs.
  • Focus on supramolecular synthesis strategies for co-crystal formation.

Related Experiment Videos

  • Case study analysis of Carbamazepine (CBZ) and Piracetam co-crystals.

    • Main Results:

    • Pharmaceutical co-crystals can be rationally designed and generated.
    • Co-crystals offer a diverse range of compositions and physical properties.
    • Case studies demonstrate the straightforward preparation of co-crystals.

    Conclusions:

    • Crystal engineering provides a powerful tool for developing novel API solid forms.
    • Pharmaceutical co-crystals represent a viable and versatile alternative to conventional API forms.
    • Rational design facilitates the creation of co-crystals with tailored properties.