Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Wilms' tumor: past, present and (possibly) future.

Filippo Spreafico1, Franca Fossati Bellani

  • 1Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy. filippo.spreafico@istitutotumori.mi.it

Expert Review of Anticancer Therapy
|February 1, 2006
PubMed
Summary

Wilms tumor treatment achieves over 85% cure rates in children through multidisciplinary care and established protocols. Ongoing research focuses on refining therapies by identifying risk factors to personalize treatment intensity for better outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bereavement in paediatric oncology: programme evaluation.

BMJ supportive & palliative care·2026
Same author

A Harmonized International Database of More Than 10,000 Pediatric Renal Tumor Patients From 30 Years of SIOP-RTSG Studies.

JCO clinical cancer informatics·2026
Same author

Characteristics and outcome of congenital mesoblastic nephroma: A report of 376 patients registered in the SIOP 93-01, SIOP WT 2001, UK-IMPORT, and AIEOP protocols.

PloS one·2026
Same author

Systematic Review: Prognostic Molecular Biomarkers in Wilms Tumors.

JCO precision oncology·2026
Same author

Robot-assisted versus conventional minimally invasive surgery in the treatment of paediatric neuroblastoma: a single-centre retrospective study.

Pediatric surgery international·2026
Same author

Development and Usability of the "FORTEe Get Strong" App to Promote Physical Activity and Health Awareness in Children and Adolescents With Cancer During Intensive Treatment Using an App-Based Approach: Mixed Methods Study.

JMIR serious games·2026

Area of Science:

  • Pediatric Oncology
  • Cancer Research
  • Clinical Trials

Background:

  • Wilms tumor has a high cure rate (>85%) in children due to effective, relatively simple therapies.
  • Multidisciplinary team approach is crucial for successful pediatric cancer treatment.
  • Major cooperative groups (National Wilms' Tumor Study, International Society of Pediatric Oncology) have guided treatment strategies.

Purpose of the Study:

  • To review current treatment strategies for Wilms tumor.
  • To provide an overview of results from significant clinical trials.
  • To discuss challenges and future directions in Wilms tumor management.

Main Methods:

  • Analysis of data from large cooperative clinical trials (National Wilms' Tumor Study and International Society of Pediatric Oncology).

Related Experiment Videos

  • Comparison of treatment approaches: primary surgery versus preoperative chemotherapy.
  • Review of advancements in managing recurrent Wilms tumor.

    • Main Results:

    • Overall cure rate for Wilms tumor exceeds 85% with current therapies.
    • Both primary surgery and preoperative chemotherapy approaches have demonstrated effectiveness.
    • Significant improvement in survival rates for recurrent Wilms tumor patients (30% to nearly 60%).

    Conclusions:

    • Wilms tumor treatment exemplifies the success of collaborative, multidisciplinary cancer care.
    • Current treatment strategies, including chemotherapy and radiotherapy, are effective but require refinement.
    • Future efforts should focus on identifying molecular and clinical risk factors to personalize treatment intensity and improve outcomes for all patients.