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Plexiform fibrohistiocytic tumor in three children
Fatemeh Jafarian1, Catherine McCuaig, Victor Kokta
1Department of Pediatric Dermatology, Ste-Justine Hospital, University of Montreal, Montreal, Quebec, Canada.
Pediatric Dermatology
|February 1, 2006
Summary
Plexiform fibrohistiocytic tumor, a rare intermediate malignancy, typically affects children and young adults. This study details three pediatric cases, highlighting clinicopathologic findings and reviewing existing literature.
Area of Science:
- Dermatopathology
- Pediatric Oncology
- Surgical Pathology
Background:
- Plexiform fibrohistiocytic tumor (PFT) is an uncommon neoplasm characterized by intermediate malignancy.
- While PFT can occur at any age, it shows a predilection for pediatric and young adult populations.
Observation:
- This report presents three pediatric cases of PFT in girls aged 8 months, 14 months, and 7 years.
- Each patient presented with a solitary, asymptomatic, subcutaneous nodule or plaque.
- Clinical and histopathological examination, including immunohistochemistry, confirmed the diagnosis of PFT.
Findings:
- The clinicopathologic features observed in these three cases align with the established characteristics of plexiform fibrohistiocytic tumor.
- Microscopic examination revealed typical PFT morphology, supported by immunohistochemical staining patterns.
- A review of the English-language literature on PFT was conducted to contextualize these findings.
Implications:
- This case series contributes to the understanding of PFT in pediatric patients.
- Accurate diagnosis and characterization of PFT are crucial for appropriate patient management.
- Further research into the pathogenesis and optimal treatment strategies for PFT is warranted.