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Related Experiment Videos

SCORPION2: a database for structure-function analysis of scorpion toxins.

Paul T J Tan1, Anitha Veeramani, Kellathur N Srinivasan

  • 1Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore, Singapore 119613. tjtan@i2r.a-star.edu.sg

Toxicon : Official Journal of the International Society on Toxinology
|February 1, 2006
PubMed
Summary

SCORPION2 is a comprehensive database for scorpion toxins, offering extensive sequence and structure data. It provides valuable tools for ion channel research and drug design, enhancing functional annotation of toxins.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Bioinformatics

Background:

  • Scorpion toxins are crucial for ion channel research and drug discovery.
  • Existing databases lack detailed structure-function information from mutation studies.

Purpose of the Study:

  • To present SCORPION2, a specialized database for scorpion toxin information.
  • To provide enhanced data and tools for researchers in ion channel and drug design fields.

Main Methods:

  • Compilation of over 800 native and mutant scorpion toxin sequences.
  • Inclusion of binding affinity, toxicity data, and 624 3D structures.
  • Development of search and prediction tools for data extraction and analysis.

Main Results:

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  • SCORPION2 offers rich annotations beyond sequence data.
  • Integrated tools facilitate text search, similarity search, structure visualization, and functional annotation.
  • The database provides access to approximately 500 references.

Conclusions:

  • SCORPION2 significantly enhances the utility of scorpion toxin data for scientific research.
  • The database serves as a valuable resource for characterizing ion channels and designing novel therapeutics.