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Related Experiment Videos

Targeting apoptosis with dietary bioactive agents.

Keith R Martin1

  • 1Department of Nutritional Sciences, The Pennsylvania State University, 126 Henderson Building South, University Park, PA 16802, USA. krm12@psu.edu

Experimental Biology and Medicine (Maywood, N.J.)
|February 1, 2006
PubMed
Summary

Dietary bioactive agents can induce apoptosis, a programmed cell death crucial for preventing cancer and maintaining health. Understanding these mechanisms offers new avenues for cancer chemoprevention through functional foods.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Nutritional Science

Background:

  • Apoptosis, or programmed cell death, is vital for cancer defense and tissue homeostasis.
  • Dysregulation of apoptosis is linked to various diseases, including cancer.
  • Diet is a significant environmental factor influencing carcinogenesis.

Purpose of the Study:

  • To review the process of apoptosis.
  • To explore the mechanistic interactions of dietary bioactive agents in apoptosis.
  • To highlight apoptosis as a therapeutic target for dietary chemoprevention.

Main Methods:

  • Literature review of apoptosis pathways (intrinsic and extrinsic).
  • Analysis of how dietary components modulate gene expression (nutritional transcriptomics).

Related Experiment Videos

  • Exploration of bioactive agents in functional foods impacting apoptosis.

    • Main Results:

    • Apoptosis involves intrinsic (mitochondrial) and extrinsic (death receptor) pathways.
    • Dietary components can directly or indirectly affect the human genome and gene expression.
    • Many diet-related genes are involved in both carcinogenesis and apoptosis.

    Conclusions:

    • Dietary interventions, particularly through functional foods, show promise for cancer prevention by inducing apoptosis.
    • Bioactive agents in the diet can act as molecular targets for chemoprevention.
    • Apoptosis is an emerging therapeutic target for dietary interventions in cancer prevention.