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Updated: Aug 13, 2026

A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
[Physiopathogenic aspects of HIV-associated primary brain lymphomas]
1Université Paris-Descartes, Faculté de médecine, Hôtel Dieu, AP-HP. sophie.camilleri-broet@htd.ap-hop-paris.fr
Abstract:
HIV-associated Primary brain lymphomas (PBLs) are usually diffuse, large B-cell lymphomas (DLBCLs). In contrast to those occurring in immunocompetent patients, nearly all HIV-associated PBLs are associated with Epstein-Barr virus (EBV). Since viral latency proteins are target antigens for anti-viral cytotoxic T lymphocytes, the double immunodeficiency (HIV infection, central nervous system microenvironment) favors the expression of viral latency proteins (LMP-1, EBNA2). These proteins play a major role in immortalization and transformation of infected B lymphocytes through cell cycle activation and apoptosis inhibition.
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