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[Multiple abscesses induced by self injection of zolpidem]

Y Scrivener1, S Maradeix, H Konaré

  • 1Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg. Jean-Nicolas.Scrivener@chru-strasbourg.fr

Annales De Dermatologie Et De Venereologie
|February 1, 2006
PubMed
Abstract

Insights

High-dose zolpidem (Ambien) abuse can lead to skin abscesses. Self-injection of powdered zolpidem revealed microcrystalline cellulose, an excipient in the pills, as the cause.

Area of Science:

  • Pharmacology
  • Dermatology
  • Toxicology

Background:

  • Zolpidem is a prescription hypnotic medication.
  • It is sometimes abused by individuals for its psychoactive effects.

Observation:

  • A case of a young female drug addict presenting with aseptic cutaneous abscesses on the forearms and feet is described.
  • These lesions resulted from the self-injection of powdered zolpidem.

Findings:

  • Histopathological examination of the abscesses revealed birefringent structures.
  • These structures were identified as microcrystalline cellulose, a common excipient in zolpidem tablets.
  • Microscopic analysis of dissolved zolpidem tablets confirmed the presence of these structures.

Implications:

  • This case highlights a novel complication of zolpidem abuse.
  • The findings suggest that self-injection of powdered zolpidem can lead to physical complications due to excipients.
  • Physicians should be aware of these potential risks in patients abusing hypnotic drugs.

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