Related Experiment Video
Updated: Aug 13, 2026
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Squamous cell carcinoma: from precursor lesions to high-risk variants
1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. smollerbrucer@uams.edu
Summary
Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer. This review explores cSCC
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer globally.
- Ultraviolet (UV) radiation exposure is a primary risk factor for cSCC development.
- Current pathology reports for cSCC often lack detailed prognostic indicators.
Purpose of the Study:
- To elucidate the biological progression of cSCC from initial development to a fully formed tumor.
- To identify and analyze histologic features of cSCC that may serve as prognostic indicators.
- To advocate for the inclusion of prognostic histologic information in pathology reports for cSCC.
Main Methods:
- Review of existing literature on cSCC biology and histology.
- Analysis of histopathologic features associated with cSCC recurrence and metastasis.
- Comparison of prognostic reporting practices for cSCC versus melanoma.
Main Results:
- cSCC arises from a multi-step biologic progression, often linked to UV damage.
- Specific histologic features within cSCC correlate with varying risks of recurrence and metastasis.
- Melanoma pathology reporting includes more prognostic detail than cSCC reporting.
Conclusions:
- Histologic examination of cSCC can identify tumors with higher metastatic potential.
- Standardizing the reporting of prognostic histologic features in cSCC is warranted.
- Improved pathology reporting can aid clinicians in patient management and treatment decisions for cSCC.
Related Concept Videos
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:24Cellular Adaptation IV: Dysplasia and Metaplasia
DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:59Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...