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Updated: Aug 13, 2026
The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
Published on: November 2, 2016
Experimental models of arteriogenesis: differences and implications
Imo E Hoefer1, Niels van Royen, Marco M Jost
1Department of Experimental Cardiology, UMC, University of Utrecht, The Netherlands. i.hoefer@azu.nl
Insights
Stimulating collateral artery growth offers a new treatment for occlusive artery disease. Researchers use animal models to study arteriogenesis and angiogenesis mechanisms for improved cardiovascular and cerebrovascular disease therapies.
Area of Science:
- Cardiovascular research
- Vascular biology
- Regenerative medicine
Background:
- Cardiovascular and cerebrovascular diseases are leading causes of death.
- Current treatments focus on restoring blood flow mechanically.
- Arteriogenesis (collateral artery growth) presents a promising alternative therapy.
Purpose of the Study:
- To review animal models for studying arteriogenesis and angiogenesis.
- To discuss mechanisms and pharmacological modulation of collateral artery growth.
- To evaluate methods for examining vascular growth.
Main Methods:
- Review of existing literature on arteriogenesis and angiogenesis animal models.
- Discussion of techniques for assessing vascular growth.
- Analysis of advantages and disadvantages of different models.
Main Results:
- Several animal models exist for studying collateral artery growth.
- Various methods are available for examining vascular development.
- Each model presents unique benefits and drawbacks for research.
Conclusions:
- Animal models are crucial for understanding arteriogenesis and angiogenesis.
- Further research is needed to optimize these models for therapeutic development.
- Stimulating collateral growth holds potential for treating occlusive artery disease.
Abstract:
Cardiovascular and cerebrovascular disease represent the two most common causes of mortality and morbidity in western countries, and the treatment for these is generally by the mechanical restoration of blood flow in the affected tissues. Stimulation of collateral artery growth (arteriogenesis) provides a potential alternative option for the treatment of patients suffering from occlusive artery disease. Therefore, researchers have established several angiogenesis and arteriogenesis animal models to investigate basic mechanisms and pharmacological modulation of collateral artery growth. The authors highlight the most important aspects of vascular growth, discuss different methods and techniques for examining the process, and review the advantages and disadvantages associated with the animal models available for studying this phenomenon.
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