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Updated: Aug 13, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
Published on: June 26, 2020
Cooperative binding and self-assembling behavior of cationic low molecular-weight dendrons with RNA molecules
Jiehua Zhou1, Jiangyu Wu, Xiaoxuan Liu
1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, PR China.
Abstract:
Tri(ethylene glycol) derived, low molecular-weight dendrons with various amine end groups were synthesized and characterized for their properties of binding and self-assembling with RNA using the Candida ribozyme as a model RNA molecule. These dendritic compounds form stable complexes and well-defined nanoscale particles with RNA molecules via electrostatic interactions and self-assembly process, while leaving the other terminal of the tri(ethylene glycol) chain accessible for targeting. This suggests that dendrimers of this type hold great promise for specific RNA targeting and RNA delivery.
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