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Updated: Jul 25, 2026
Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking
Published on: October 10, 2019
[Prostate cancer diagnosis using 24 cores extended biopsy]
A Rodríguez Alonso1, A González Blanco, S Pita Fernandez
1Servicios de Urología, Hospital Arquitecto Marcide, Ferrol, La Coruña. arodri68@terra.es
Extended prostatic biopsy (PB) detects prostate cancer (PC) in 40.82% of patients with prior negative biopsies. Higher PSA density increases PC probability, while chronic prostatitis decreases it.
Area of Science:
- Urology
- Oncology
- Diagnostic Imaging
Context:
- Prostate cancer (PC) diagnosis often requires repeat biopsies.
- Evaluating diagnostic performance of extended prostatic biopsy (PB) is crucial for patient management.
Purpose:
- To assess the diagnostic utility of an extended 24-cylinder prostatic biopsy (PB) for detecting prostate cancer (PC).
- To identify clinical and biochemical variables associated with positive extended PB results.
Summary:
- An extended 24-cylinder prostatic biopsy (PB) diagnosed PC in 40.82% of patients with previous negative biopsies.
- Factors positively associated with extended PB positivity included prostatic volume, PSA-density, and initial/extended free/total PSA ratio.
- Chronic prostatitis in prior biopsies was found to independently predict lower positivity rates in extended PB.
Impact:
- Extended PB improves PC detection rates in patients with prior negative biopsies.
- PSA-density is a key indicator for PC detection via extended PB.
- Understanding factors like chronic prostatitis can refine biopsy strategies and improve diagnostic accuracy.
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