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Highly porous fibers by electrospinning into a cryogenic liquid

Jesse T McCann1, Manuel Marquez, Younan Xia

  • 1Department of Chemistry, University of Washington, Seattle, Washington 98195-1700, USA.

Journal of the American Chemical Society
|February 2, 2006
PubMed

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...