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Malignant peripheral nerve sheath tumor of the kidney

Stephen B Williams1, Gregory R Szlyk, Michael J Manyak

  • 1Department of Urology, The George Washington University Medical Center, Washington, DC 20037, USA.

International Journal of Urology : Official Journal of the Japanese Urological Association
|February 2, 2006
PubMed

Insights

Malignant peripheral nerve sheath tumors are rare in the kidney. This case highlights a patient with a renal tumor alongside scalp, lung, and shoulder masses, treated with chemotherapy and surgery.

Area of Science:

  • Oncology
  • Nephrology
  • Surgical Pathology

Background:

  • Malignant peripheral nerve sheath tumors (MPNSTs) are uncommon neoplasms.
  • Genitourinary involvement, particularly in the kidney, is exceptionally rare for MPNSTs.

Observation:

  • A patient presented with a renal MPNST discovered after excision of a scalp MPNST.
  • Metastatic evaluation revealed additional MPNSTs in the lung and shoulder.

Findings:

  • The patient received neoadjuvant intravenous doxorubicin chemotherapy.
  • Surgical resection was performed for scalp, lung, shoulder lesions, and a radical nephrectomy for the renal tumor.

Implications:

  • This case expands the understanding of rare renal MPNST occurrences.
  • It underscores the importance of thorough metastatic evaluation for MPNSTs.
  • Multimodal treatment including chemotherapy and surgery can be effective.

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