Related Experiment Video
Updated: Aug 13, 2026

In situ Imaging of the Mouse Thymus Using 2-Photon Microscopy
Published on: January 25, 2008
Establishment and functioning of intrathymic microenvironments
Graham Anderson1, William E Jenkinson, Terry Jones
1MRC Center for Immune Regulation, Division of Immunity and Infection, Institute For Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK. g.anderson@bham.ac.uk
Abstract:
The thymus supports the production of self-tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of stromal microenvironments within the thymus therefore is essential to our understanding of T-cell production and ultimately immune system functioning. Despite our ability to phenotypically define stromal cell compartments of the thymus, the mechanisms regulating their development and the ways by which they influence T-cell precursors are still unclear. Here, we review recent findings and highlight unresolved issues relating to the development and functioning of thymic stromal cells.
Related Concept Videos
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Microenvironments
Regulation of Hormone Secretion
Humoral stimuli,...
The Tumor Microenvironment

