Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reflection impulsivity in current and former substance users.

Luke Clark1, Trevor W Robbins, Karen D Ersche

  • 1Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom.

Biological Psychiatry
|February 2, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shifts in the brain sex continuum in major depressive disorder: Evidence for a persistent neurobiological marker.

Journal of affective disorders·2026
Same author

Multimodal fusion of brain imaging and proteomics reveals a brain-body pathway linking depression and metabolic dysfunction.

Psychological medicine·2026
Same author

Set-shifting and task-switching make differential contributions to divergent thinking in adolescence.

BMC psychology·2026
Same author

Accelerated continuous theta burst stimulation targeting left primary motor cortex for children with autism spectrum disorder: multicentre randomised sham controlled trial.

BMJ (Clinical research ed.)·2026
Same author

The association between prenatal exposure to cannabis with and without tobacco and early cognitive and language development in a sample of polysubstance-exposed children.

Early human development·2026
Same author

Peripheral Expression of Dopamine Genes as a Biomarker for Cocaine Addiction in Humans.

European addiction research·2026
Same journal

Neuroimaging of Heterogeneity in Neuropsychiatric Disorders: Toward Disease Progression Modeling.

Biological psychiatry·2026
Same journal

Impact of Transcranial Direct Current Stimulation-Induced Electric Fields on Slowing Cognitive Decline in Older Adults With Mild Cognitive Impairment or Remitted Major Depressive Disorder: An Analysis of the PACt-MD Randomized Clinical Trial.

Biological psychiatry·2026
Same journal

Remembering Jon-Kar Zubieta, M.D., Ph.D.

Biological psychiatry·2026
Same journal

Kappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [<sup>11</sup>C]EKAP PET imaging.

Biological psychiatry·2026
Same journal

From Satiety to Substance Use: Neural Mechanisms of GLP-1 Signaling in Appetite and Reward.

Biological psychiatry·2026
Same journal

Distinct and Shared Molecular Mechanisms Underlie Morphological-Functional Overcoupling and Undercoupling in Major Depressive Disorder.

Biological psychiatry·2026
See all related articles

Chronic drug use impairs decision-making by reducing reflection, a tendency to gather information before acting. This cognitive deficit persists even after long-term abstinence from amphetamines and opiates.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Addiction Research

Background:

  • Chronic drug use is linked to impulsivity and poor decision-making.
  • The neurocognitive mechanisms underlying these effects are not fully understood.
  • Reflection impulsivity, the tendency to seek information before deciding, was investigated.

Purpose of the Study:

  • To investigate reflection impulsivity in individuals with substance dependence.
  • To determine if reduced reflection is a cognitive marker for substance dependence.
  • To assess the persistence of reduced reflection after prolonged abstinence.

Main Methods:

  • The Information Sampling Task was used to measure reflection impulsivity.
  • Participants included current amphetamine/opiate users, abstinent former users, and controls.

Related Experiment Videos

  • Impulsivity was also assessed using the Barratt Impulsivity Scale (version 11).

    • Main Results:

    • Current amphetamine and opiate users sampled less information than controls.
    • Reduced reflection was observed in current users and persisted in former users abstinent for over a year.
    • Self-reported impulsivity was elevated in substance users but not correlated with task performance.

    Conclusions:

    • Reduced reflection appears to be a cognitive marker for substance dependence.
    • This deficit does not recover with prolonged abstinence.
    • Reduced reflection is associated with multiple drugs of abuse, including amphetamines and opiates.