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Related Experiment Videos

Breastfeeding during tacrolimus therapy.

Sharon J Gardiner1, Evan J Begg

  • 1Department of Medicine, Christchurch School of Medicine and Christchurch Hospital, Christchurch, New Zealand. sharon.gardiner@cdhb.govt.nz

Obstetrics and Gynecology
|February 2, 2006
PubMed
Summary

Breastfeeding is likely safe for mothers taking tacrolimus, an immunosuppressant. Infant exposure to tacrolimus through breast milk is minimal, supporting its compatibility with breastfeeding post-transplant.

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Area of Science:

  • Pharmacology
  • Transplant Medicine
  • Lactation Studies

Background:

  • Solid organ transplant recipients often avoid breastfeeding due to immunosuppressant concerns.
  • Limited data exist on infant exposure to tacrolimus (immunosuppressant) via breast milk.
  • This study quantifies tacrolimus transfer into breast milk.

Observation:

  • A renal transplant patient exclusively breastfed her 3-month-old infant while on tacrolimus.
  • The milk-to-blood ratio for tacrolimus was determined to be 0.23.
  • Average tacrolimus levels in breast milk were 1.8 microg/L.

Findings:

  • Infant tacrolimus ingestion was approximately 0.5% of the maternal dose (weight-adjusted).
  • Tacrolimus transfer into breast milk is low.

Related Experiment Videos

  • Maternal tacrolimus therapy demonstrated minimal infant exposure.

    • Implications:

    • Tacrolimus therapy may be compatible with breastfeeding in solid organ transplant recipients.
    • Provides evidence to guide clinical decisions regarding breastfeeding post-transplant.
    • Supports the safety of tacrolimus for nursing infants.