Related Experiment Video
Updated: Aug 13, 2026
06:31
Erosion Identification in Metacarpophalangeal Joints in Rheumatoid Arthritis using High-Resolution Peripheral Quantitative Computed Tomography
Published on: October 6, 2023
Association between PADI4 and rheumatoid arthritis: a meta-analysis
T Iwamoto1, K Ikari, T Nakamura
1Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada, Shinjuku, Tokyo 162-0054, Japan.
Rheumatology (Oxford, England)
|February 2, 2006
Summary
This meta-analysis confirms a link between the PADI4 gene and rheumatoid arthritis (RA). The peptidylarginine deiminase type 4 (PADI4) gene shows association with RA in both Japanese and European populations.
Area of Science:
- Genetics
- Rheumatology
- Immunology
Background:
- Polymorphisms and haplotypes of the peptidylarginine deiminase type 4 gene (PADI4) have been associated with rheumatoid arthritis (RA) in Japanese populations.
- Conflicting results from subsequent replication studies necessitate further investigation.
- A meta-analysis is required to definitively establish the association between PADI4 and RA.
Purpose of the Study:
- To determine if a meta-analysis can confirm the association between PADI4 gene polymorphisms/haplotypes and rheumatoid arthritis.
- To consolidate findings from existing replication studies on PADI4 and RA.
- To evaluate the PADI4-RA association across different ethnic groups.
Main Methods:
- A comprehensive PubMed search was conducted for 'PADI4' related articles up to December 2005.
- Replication studies investigating the PADI4-RA association were selected for meta-analysis.
- The Mantel-Haenszel procedure was employed to pool odds ratios (OR) with 95% confidence intervals (CI), and the Breslow-Day test assessed study homogeneity.
Main Results:
- Six replication studies (one Japanese, five European/North American) met the inclusion criteria.
- Homogeneity was confirmed across the included replication studies.
- A significant association was found for allelic distribution (common OR = 1.14, 95% CI = 1.07-1.21), further confirmed in European descent populations (P = 0.0096, common OR = 1.10).
Conclusions:
- The meta-analysis demonstrates a positive association between the PADI4 gene and rheumatoid arthritis.
- This association is evident not only in the Japanese population but also extends to populations of European descent.
- The findings support PADI4 as a potential genetic factor contributing to RA pathogenesis across diverse ethnic groups.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
01:20The JAK-STAT Signaling Pathway
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
01:23Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
01:20Rheumatic Heart Disease IV: Nursing Management
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...