Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relations between structure and function of the mitochondrial ADP/ATP carrier.

H Nury1, C Dahout-Gonzalez, V Trézéguet

  • 1Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075 CEA-CNRS-Université Joseph Fourier, F-38027 Grenoble cedex 1, France. hugues.nury@ibs.fr

Annual Review of Biochemistry
|February 3, 2006
PubMed
Summary

Mitochondrial ADP/ATP carriers, key members of the mitochondrial carrier family (MCF), regulate metabolite transport across the inner mitochondrial membrane. Their structure and function are crucial for cellular energy production.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crystallization of the membrane protein hVDAC1 produced in cell-free system.

Biochimica et biophysica acta·2010
Same author

Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier.

Physiology (Bethesda, Md.)·2006
Same author

Structural basis for lipid-mediated interactions between mitochondrial ADP/ATP carrier monomers.

FEBS letters·2005
Same author

Spectroscopic characterization of bacteriorhodopsin's L-intermediate in 3D crystals cooled to 170 K.

Photochemistry and photobiology·2002
Same author

Fluorometric detection of ADP/ATP carrier deficiency in human muscle.

Clinica chimica acta; international journal of clinical chemistry·2001
Same author

Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation.

Biochemistry·2001

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Mitochondrial membranes tightly control metabolite transport.
  • The mitochondrial carrier family (MCF) comprises essential transport proteins.
  • The ADP/ATP carrier is abundant and well-studied within MCF.

Purpose of the Study:

  • To detail the structure and function of the ADP/ATP carrier.
  • To elucidate the transport mechanism of ADP/ATP across the mitochondrial inner membrane.
  • To discuss nucleotide recognition and conformational changes involved in transport.

Main Methods:

  • Structural analysis of the ADP/ATP carrier.
  • Biochemical assays to study protein function.
  • Functional studies to understand transport mechanisms.

Related Experiment Videos

Main Results:

  • The ADP/ATP carrier has a basket-shaped structure with six transmembrane helices.
  • Three transmembrane helices are kinked due to proline residues.
  • Structural data suggests mechanisms for nucleotide binding and conformational changes.

Conclusions:

  • The structure of the ADP/ATP carrier provides insights into its transport mechanism.
  • Understanding ADP/ATP carrier function is vital for cellular energy homeostasis.
  • Further research can build upon the known structure and biochemical data.