Related Experiment Video
Updated: Aug 4, 2026

DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
Published on: July 21, 2014
DeoT, a DeoR-type transcriptional regulator of multiple target genes
Maya Elgrably-Weiss1, Eliana Schlosser-Silverman, Ilan Rosenshine
1Department of Molecular Genetics and Biotechnology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Abstract:
In this study, we investigated the genetic organization and function of Escherichia coli yciT, a gene predicted by computational methods to belong to the DeoR-type family of transcriptional regulators. We show that transcription of yciT (here denoted deoT for deoR-Type) initiates from a promoter located upstream of a putative open reading frame (denoted deoL for deoT Leader). We also show that DeoT acts as a global regulator, repressing the expression of a number of genes involved in a variety of metabolic pathways including transport of maltose, fatty acid beta-oxidation and peptide degradation.
More Related Videos
Related Concept Videos
RNA Polymerase II Accessory Proteins
Co-activators and Co-repressors
Master Transcription Regulators
Cooperative Binding of Transcription Regulators
Co-activators and Co-repressors
Master Transcription Regulators

