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Updated: Aug 13, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Comparison of marker types and map assumptions using Markov chain Monte Carlo-based linkage analysis of COGA data
Weiva Sieh1, Saonli Basu, Audrey Q Fu
1Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA. wsieh@u.washington.edu
Abstract:
We performed multipoint linkage analysis of the electrophysiological trait ECB21 on chromosome 4 in the full pedigrees provided by the Collaborative Study on the Genetics of Alcoholism (COGA). Three Markov chain Monte Carlo (MCMC)-based approaches were applied to the provided and re-estimated genetic maps and to five different marker panels consisting of microsatellite (STRP) and/or SNP markers at various densities. We found evidence of linkage near the GABRB1 STRP using all methods, maps, and marker panels. Difficulties encountered with SNP panels included convergence problems and demanding computations.
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