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Modeling the effect of an associated single-nucleotide polymorphism in linkage studies

Jeanine J Houwing-Duistermaat1, Hae-Won Uh, Jeremie J P Lebrec

  • 1Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands. j.j.houwing@lumc.nl

BMC Genetics
|February 3, 2006
PubMed
Summary

This study introduces a regression model for linkage analysis in affected sibling pairs, incorporating disease-associated single-nucleotide polymorphism data. The model aims to determine if specific markers explain linkage peaks, using parent and sibling genotypes.

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