Related Experiment Video
Updated: Aug 13, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Analysis of binary traits: testing association in the presence of linkage
Gudrun Jonasdottir1, Juni Palmgren, Keith Humphreys
1Department of Mathematical Statistics, Stockholm University, Sweden. gudrun.jonasdottir@ki.se
Abstract:
Most methods for testing association in the presence of linkage, using family-based studies, have been developed for continuous traits. FBAT (family-based association tests) is one of few methods appropriate for discrete outcomes. In this article we describe a new test of association in the presence of linkage for binary traits. We use a gamma random effects model in which association and linkage are modelled as fixed effects and random effects, respectively. We have compared the gamma random effects model to an FBAT and a generalized estimating equation-based alternative, using two regions in the Genetic Analysis Workshop 14 simulated data. One of these regions contained haplotypes associated with disease, and the other did not.
More Related Videos
Related Concept Videos
Pedigree Analysis
Pedigree Analysis
Dihybrid Crosses
Dihybrid Crosses
Epistasis Analysis
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...

