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Antioxidant intake, GSTM1 polymorphism and pulmonary function in healthy young adults
J Tujague1, M Bastaki, N Holland
1Division of Epidemiology, School of Public Health, University of California, Berkeley 94720-7360, USA.
The European Respiratory Journal
|February 3, 2006
Summary
Dietary vitamin C and magnesium intake positively correlate with improved lung function in healthy adolescents. Genetic variations in glutathione S-transferase M1 (GSTM1) did not significantly impact lung function in this study.
Area of Science:
- Environmental health
- Nutritional science
- Pulmonology
Background:
- Dietary antioxidants are crucial for protecting lung tissue from oxidative stress and maintaining pulmonary function.
- Individual responses to oxidative stress in the lungs can be influenced by genetic variations in antioxidant enzymes.
Purpose of the Study:
- To investigate the association between dietary antioxidant intake and lung function levels.
- To determine the role of glutathione S-transferase M1 (GSTM1) polymorphism in lung function.
Main Methods:
- A cohort of healthy, nonsmoking college freshmen with known residential histories completed food frequency and health questionnaires.
- Blood samples were collected for glutathione S-transferase M1 (GSTM1) genotyping.
- Lung function was assessed using forced expiratory volume measurements.
Main Results:
- Dietary vitamin C, magnesium, and fruit intake showed a positive association with lung function parameters in both males and females.
- Specifically, vitamin C and magnesium intake were consistently linked to better lung function in multivariable regression analyses.
- The study found no evidence to support the glutathione S-transferase M1-null genotype as an independent risk factor for reduced lung function.
Conclusions:
- Dietary intake of vitamin C and magnesium is associated with enhanced lung function in healthy adolescents.
- Vitamin C intake, in particular, showed a significant positive association with lung function in female adolescents.
- Glutathione S-transferase M1 (GSTM1) genotype does not appear to be a significant factor in determining lung function decrements in this population.
