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Non-invasive Parenchymal, Vascular and Metabolic High-frequency Ultrasound and Photoacoustic Rat Deep Brain Imaging
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Ultrasound perfusion imaging of cysts in the midbrain

C H Nolte1, J Gruss, J Steinbrink

  • 1Department of Neurology, University Hospital Charite Berlin. christian.nolte@charite.de

Ultraschall in Der Medizin (Stuttgart, Germany : 1980)
|February 3, 2006
PubMed
Abstract

Insights

Phase-Inversion-Harmonic-Imaging (PIHI) successfully visualized mesencephalic perfusion abnormalities in a patient with ponto-mesencephalic cysts. This technique accurately delineated the extent of the cystic structures, demonstrating diminished contrast agent influx.

Area of Science:

  • Neuroimaging
  • Cerebral Perfusion
  • Ultrasound Technology

Background:

  • Cerebral ultrasound perfusion imaging traditionally focuses on the diencephalic region.
  • Mesencephalic perfusion assessment remains less explored.
  • Magnetic Resonance Imaging (MRI) is often used to define structural abnormalities.

Observation:

  • Phase-Inversion-Harmonic-Imaging (PIHI) was utilized with a Siemens Sonoline Elegra ultrasound system.
  • Contrast-enhanced ultrasound (CEUS) using SonoVue assessed bolus kinetics.
  • Quantification of signal increase included peak-signal-increase (PSI) and time-to-peak (TTP).

Findings:

  • PIHI enabled quantification of perfusion parameters (PSI, TTP) in the mesencephalon, posterior cerebral arteries, middle cerebral artery, and temporal lobe.
  • Diminished or absent contrast agent influx was observed in the area of ponto-mesencephalic cysts.
  • Perfusion parameters effectively delineated the boundaries of the cystic lesions.

Implications:

  • PIHI is a feasible technique for evaluating mesencephalic perfusion.
  • This method allows for the identification of pathological structures within the mesencephalon.
  • CEUS with PIHI offers a valuable tool for characterizing lesions in this brain region.

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