Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RepairNET: a bioinformatics toolbox for functional exploration of DNA damage response.

Wei Li1, Liting Wen, Jin-An Feng

  • 1Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA.

Journal of Cellular Physiology
|February 3, 2006
PubMed
Summary

RepairNET is a new protein network detailing DNA damage response pathways. This resource aids cancer research by mapping protein interactions and signaling crucial for genomic integrity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Use of Non-Contrast Abbreviated MRI for the Detection of Recurrent Hepatocellular Carcinoma in Postoperative Surveillance.

Journal of magnetic resonance imaging : JMRI·2026
Same author

Divergent Synthesis of Homoallylic and Allenic Sulfides, Selenides, and S,C-Sulfonium Ylides by Ruthenium Catalysis.

Precision chemistry·2026
Same author

Development and validation of A CCTA-based risk prediction model for major adverse cardiovascular events in esophageal cancer patients receiving radiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

TFAP2B governs the regulation of SIRT1 to inhibit osteoclast-induced bone destruction.

Biochemical and biophysical research communications·2025
Same author

Health-related quality of life profiles in patients with rheumatoid arthritis: a latent profile analysis.

Frontiers in public health·2025
Same author

Prediction of therapeutic response to transarterial chemoembolization plus systemic therapy regimen in hepatocellular carcinoma using pretreatment contrast-enhanced MRI based habitat analysis and Crossformer model.

Abdominal radiology (New York)·2024

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • DNA damage response (DDR) is critical for maintaining genomic stability.
  • Dysregulation of DDR pathways is a hallmark of many cancers.
  • Understanding DDR signaling is essential for cancer research and therapeutic development.

Purpose of the Study:

  • To introduce RepairNET, a comprehensive protein-protein interaction network for DNA damage response.
  • To provide a user-friendly platform for exploring DDR pathways and protein functions.
  • To facilitate research into the mechanisms of DNA damage response and cancer proliferation.

Main Methods:

  • Assembled RepairNET using computational data mining of MEDLINE and manual curation.
  • Developed a Java-based interactive graphical interface for network navigation.

Related Experiment Videos

  • Assigned functional domains to proteins based on sequence analysis.

    • Main Results:

    • RepairNET contains over 1,200 proteins and 2,300 functional interactions.
    • 365 unique functional domains have been assigned to proteins within the network.
    • A web interface with navigation and domain assignment tools is available online.

    Conclusions:

    • RepairNET serves as a valuable resource for cancer research.
    • The network aids in understanding protein functional relationships in DDR.
    • RepairNET supports the development of scientific models for DNA damage response and cancer.