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Subcutaneous Administration of Muscarinic Antagonists and Triple-Immunostaining of the Levator Auris Longus Muscle in Mice
Published on: September 8, 2011
Cholinergic neuromuscular hyperactivity in patients with myasthenia gravis seropositive for MuSK antibody
Anna Rostedt Punga1, Roland Flink, Håkan Askmark
1Department of Clinical Neurophysiology, University Hospital, S-75185 Uppsala, Sweden.
Abstract:
A 75-year-old man with severe oculobulbar myasthenia gravis (MG) treated with acetylcholine esterase inhibitors (AChEIs) was found to have muscle-specific tyrosine kinase (MuSK) antibodies. Neurophysiological examination displayed extra repetitive discharges after the compound motor action potential (CMAP) at low-frequency stimulation, possibly triggered by AChEI. This indicates an abnormal sensitivity to acetylcholine in patients with MuSK antibodies and may be a useful indicator of the adverse effect of AChEI treatment in these patients.
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