Related Experiment Video

Updated: Aug 13, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

Broad substrate specificity of ketoreductases derived from modular polyketide synthases

Shilpa Bali1, Helen M O'Hare, Kira J Weissman

  • 1Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

Chembiochem : a European Journal of Chemical Biology
|February 3, 2006
PubMed
Summary

Recombinant ketoreductase (KR) enzymes from polyketide synthases (PKSs) show promise for creating chiral alcohols. Mutagenesis improved their ability to reduce non-polyketide substrates, enabling new biotransformation applications.

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