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The biological activity of atrial natriuretic factor cleaved by endoprotease 3.4.24.11
R D Ghai1, R L Webb, J L Sonnenberg
1Research Department, CIBA-GEIGY Corporation, Summit, New Jersey 07901.
Journal of Enzyme Inhibition
|January 1, 1991
Abstract:
Ring cleavage of atrial natriuretic peptide (ANF) between Cys7 and Phe8 by endoprotease 3.4.24.11 yields X-ANF. Since endoprotease 3.4.24.11 may contribute to ANF metabolism in vivo, the present study determined if X-ANF exhibits reduced biological activity in comparison to the parent molecule.