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Leptin levels in pre and post menopausal Pakistani women
Nishat Ayub1, Sohail Rafi Khan, Fauzia Syed
1Department of Biochemistry, Karachi Medical and Dental College, Karachi University.
Objective:
To evaluate the correlation of fasting serum leptin levels with anthropometric measurements and menopausal status, in women.
Methods:
The study comprised of 80 non-obese women who were divided into 2 groups as pre-menopausal (n=46) and post-menopausal (n=34). Anthropometric measurements i.e. height, weight, waist and hip circumference were measured for all the subjects and the Waist-hip Ratio (WHR) and Body Mass Index (BMI) were calculated from these measurements. A fasting venous blood sample was taken from all the subjects and serum leptin concentrations were determined by ELISA.
Results:
A comparison of the mean values for BMI and WHR between the two groups showed a non significant difference. Within each group, significant associations were noted between the fasting serum leptin level and values of BMI and WHR. A comparison of the mean serum leptin concentrations between the two groups, showed a highly significant difference (p<0.001).
Conclusion:
Our results indicate that in the non-obese women of our population, leptin levels associate with BMI and WHR and together with menopausal status seem to be important determinants of serum leptin levels.
