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Updated: Aug 12, 2026

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
Published on: April 16, 2019
[Supramolecular nanocarrier for gene and siRNA delivery]
Keiji Itaka1, Ung-Il Chung, Kazunori Kataoka
1Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo.
Abstract:
In this review article, supramolecular nanocarriers for gene and siRNA delivery were introduced. They were formed through the multimolecular assembly of block copolymers, containing the DNA or siRNA inside the core of the micelle structure. Due to the excellent stability under the physiological conditions, low toxic effect, and controllable gene functions, this system should be a promising candidate for in vivo therapeutic applications including the non-lethal diseases and the tissue engineering.
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