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Related Experiment Videos

Interobserver agreement on microfollicles in thyroid fine-needle aspirates.

Andrew A Renshaw1, Edward Wang, David Wilbur

  • 1Department of Pathology, Baptist Hospital of Miami, Miami, FL 33176-2197, USA.

Archives of Pathology & Laboratory Medicine
|February 4, 2006
PubMed
Summary

Consistent classification of thyroid microfollicles requires specific features. Reproducible microfollicles have fewer than 15 cells, a circular arrangement with a lumen, and are flat.

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Area of Science:

  • Cytopathology
  • Thyroid Neoplasms
  • Histopathology

Background:

  • Microfollicles are a recognized feature in thyroid fine-needle aspirates.
  • The diagnostic consistency of classifying cellular groups as microfollicles is currently unknown.

Purpose of the Study:

  • To identify specific morphological features associated with consistent microfollicle classification.
  • To improve interobserver agreement in the interpretation of thyroid fine-needle aspirates.

Main Methods:

  • Twelve cytopathologists evaluated 45 small follicular cell groups from thyroid fine-needle aspirates.
  • Groups were classified as microfollicles, macrofollicles, or indeterminate.

Main Results:

  • Twenty groups were consistently classified as microfollicles, characterized by <15 cells, a circular arrangement with a lumen (≥2/3 complete), and flatness.

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  • Macrofollicles (7 groups) had 8-35 cells, arranged in sheets or rows.
  • Indeterminate groups (18) included 3D structures, small flat groups, or single cells.

    • Conclusions:

    • Not all small follicular cell groups are consistently identified as microfollicles.
    • Established criteria (e.g., <15 cells, circular, flat) enhance reproducible microfollicle classification.
    • Improved classification consistency can lead to more reliable thyroid fine-needle aspirate diagnoses.