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Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay
Published on: September 2, 2014
Predominant expression of rTERTb, an inactive TERT variant, in the adult rat brain
Ryosuke Kaneko1, Shigeyuki Esumi, Takeshi Yagi
1Laboratory of Neurobiology and Behavioural Genetics, National Institute for Physiological Sciences, Okazaki 444-8787, Japan. rkaneko@nips.ac.jp
Protein and Peptide Letters
|February 4, 2006
Abstract:
The full-length and four alternatively spliced variant mRNA transcripts of rat TERT were identified. One of the variant, rTERTb, was predominantly expressed during brain development in accordance with the decrease in telomerase activity. The rTERTb mRNA encoded an inactive truncated protein. Alternative splicing of TERT may be important during brain development.
