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Updated: Aug 11, 2026
A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Published on: February 7, 2015
Validation of a carotid intima-media thickness border detection program for use in an office setting
Adam D Gepner1, Claudia E Korcarz, Susan E Aeschlimann
1Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin Medical School, Madison, WI 53792, USA.
Background:
A unique semiautomated border detection program (BDP) designed for use on a personal computer was evaluated to determine whether: (1) carotid intima-media thickness (CIMT) measurements were bioequivalent to a reference laboratory; and (2) it would allow a novice (NOV) reader with no medical training to accurately and reproducibly measure CIMT.
Methods:
Far-wall CIMT was measured blindly and in duplicate by an experienced and NOV reader using BDP and by a reference laboratory.
Results:
Mean CIMT using BDP was bioequivalent to the reference laboratory (two 1-sided T-test, P < .05) with small absolute differences (experienced 0.011 +/- 0.004 mm, NOV 0.022 +/- 0.004 mm). Reproducibility was high, with small coefficients of variation when used by either the experienced (3.1%) or NOV (7.8%) reader.
Conclusion:
CIMT measurements using BDP were accurate and reproducible. It was mastered easily by a NOV reader and appeared suitable for use in an office setting.
